This is an update to the NICE guideline from 2008 on managing familial hypercholesterolaemia. Basically ezetimibe is now recommended as monotherapy in treatment if:
- patients can not tolerate statin therapy.
- statin therapy is contra-indicated.
Ezetimibe can be use as add-on therapy to statins if:
- total cholesterol or LDL cholesterol is not controlled by appropriate statin use.
- a change from one statin to an alternative statin is being considered.