Familial hypercholesterolaemia and ezetimibe

This is an update to the NICE guideline from 2008 on managing familial hypercholesterolaemia. Basically ezetimibe is now recommended as monotherapy in treatment if:

  • patients can not tolerate statin therapy.
  • statin therapy is contra-indicated.

Ezetimibe can be use as add-on therapy to statins if:

  • total cholesterol or LDL cholesterol is not controlled by appropriate statin use.
  • a change from one statin to an alternative statin is being considered.

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